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Index > Protein center > Pnpla2(Gene name) > Rat
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  • Pnpla2 (Gene name),
  • Patatin-like phospholipase domain-containing protein 2 (Protein name ),  PLPL2_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Pnpla2(Atgl);
    Protein name:
    Patatin-like phospholipase domain-containing protein 2;
    Alternative:
    Adipose triglyceride lipase;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with ABHD5; this association stimulates PNPLA2 triglyceride hydrolase activity (By similarity). Interacts with SERPINF1; interacts at one site of interaction (By similarity). Despite a colocalization in lipid droplets, it probably does not interact with PLIN.
    Function:
    Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.
    Subcellular Location:
    Lipid droplet Cell membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    478
    Sequence:
    50:
    MFPRETKWNI | SFAGCGFLGV | YHIGVASCLR | EHAPFLVANA | THIYGASAGA | 
    100:
    LTATALVTGA | CLGEAGANII | EVSKEARKRF | LGPLHPSFNL | VKTIRGCLLK | 
    150:
    TLPADCHTRA | SGRLGISLTR | VSDGENVIIS | HFSSKDELIQ | ANVCSTFIPV | 
    200:
    YCGLIPPTLQ | GVRYVDGGIS | DNLPLYELKN | TITVSPFSGE | SDICPQDSST | 
    250:
    NIHELRITNT | SIQFNLRNLY | RLSKALFPPE | PMVLREMCKQ | GYRDGLRFLR | 
    300:
    RNGLLNQPNP | LLALPPVVPQ | EEDAEEAAVT | EERTGGEDRI | LEHLPARLNE | 
    350:
    ALLEACVEPK | DLMTTLSNML | PVRLATAMMV | PYTLPLESAV | SFTIRLLEWL | 
    400:
    PDVPEDIRWM | KEQTGSICQY | LVMRAKRKLG | DHLPSRLSEQ | VELRRAQSLP | 
    450:
    SVPLSCATYS | EALPNWVRNN | LSLGDALAKW | EECQRQLLLG | LFCTNVAFPP | 
    478:
    DALRMRAPAS | PTATDPATPQ | DPSGLPPC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Patatin-like phospholipase domain-containing protein 2
    Cat.:
    E8796h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat Patatin-like phospholipase domain-containing protein 2
    Cat.:
    E8796r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat Patatin-like phospholipase domain-containing protein 2
    Cat.:
    E8796m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat Patatin-like phospholipase domain-containing protein 2
    Cat.:
    E8796b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Patatin-like phospholipase domain-containing protein 2
    Cat.:
    U8796m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Patatin-like phospholipase domain-containing protein 2
    Cat.:
    U8796b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Patatin-like phospholipase domain-containing protein 2
    Cat.:
    U8796r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Patatin-like phospholipase domain-containing protein 2
    Cat.:
    U8796h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Rat Patatin-like phospholipase domain-containing protein 2
    Polyclonal Antibody for Rat Patatin-like phospholipase domain-containing protein 2
    Cat.:
    P8796Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Patatin-like phospholipase domain-containing protein 2
    Polyclonal Antibody for Rat Patatin-like phospholipase domain-containing protein 2
    Cat.:
    P8796Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Patatin-like phospholipase domain-containing protein 2
    Monoclonal Antibody for Rat Patatin-like phospholipase domain-containing protein 2
    Monoclonal Antibody for Rat Patatin-like phospholipase domain-containing protein 2
    Monoclonal Antibody for Rat Patatin-like phospholipase domain-containing protein 2
    Protein for Rat Patatin-like phospholipase domain-containing protein 2
    Protein for Rat Patatin-like phospholipase domain-containing protein 2
    Protein for Rat Patatin-like phospholipase domain-containing protein 2
    Protein for Rat Patatin-like phospholipase domain-containing protein 2

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    Precision
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    Linearity
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    References
    1. 1.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    2. 2.
      "PPARgamma agonism increases rat adipose tissue lipolysis, expression of glyceride lipases, and the response of lipolysis to hormonal control."
      Festuccia W.T. , Laplante M. , Berthiaume M. , Gelinas Y. , Deshaies Y.
      Diabetologia49:2427-2436(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    3. 3.
      "Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contraction."
      MacPherson R.E. , Ramos S.V. , Vandenboom R. , Roy B.D. , Peters S.J.
      Am. J. Physiol.304:R644-R650(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLIN5
    4. 4.
      "Skeletal muscle PLIN3 and PLIN5 are serine phosphorylated at rest and following lipolysis during adrenergic or contractile stimulation."
      Macpherson R.E. , Vandenboom R. , Roy B.D. , Peters S.J.
      Physiol. Rep.1:E00084-E00084(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLIN5
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